diff --git a/lib/shared/dm-ops/change-thread-settings-spec.js b/lib/shared/dm-ops/change-thread-settings-spec.js
--- a/lib/shared/dm-ops/change-thread-settings-spec.js
+++ b/lib/shared/dm-ops/change-thread-settings-spec.js
@@ -6,6 +6,7 @@
 import type {
   DMOperationSpec,
   ProcessDMOperationUtilities,
+  ProcessingPossibilityCheckResult,
 } from './dm-op-spec.js';
 import type {
   DMBlobOperation,
@@ -198,16 +199,51 @@
       dmOperation: DMChangeThreadSettingsOperation,
       utilities: ProcessDMOperationUtilities,
     ) => {
-      if (utilities.threadInfos[dmOperation.threadID]) {
+      const { fieldNameToMessageData } =
+        createChangeSettingsMessageDatasAndUpdate(dmOperation);
+      const messageIDConflictCheckPromises: $ReadOnlyArray<
+        Promise<ProcessingPossibilityCheckResult>,
+      > = values(fieldNameToMessageData).map(async ({ rawMessageInfo }) => {
+        if (!rawMessageInfo.id) {
+          return { isProcessingPossible: true };
+        }
+        const messageID = rawMessageInfo.id;
+        const message = await utilities.fetchMessage(messageID);
+        if (message) {
+          console.log(
+            `Discarded a ${dmOperation.type} operation because ` +
+              `message with the same ID ${messageID} already exists ` +
+              'in the store',
+          );
+          return {
+            isProcessingPossible: false,
+            reason: {
+              type: 'invalid',
+            },
+          };
+        }
         return { isProcessingPossible: true };
+      });
+
+      const messageIDConflictCheckResults = await Promise.all(
+        messageIDConflictCheckPromises,
+      );
+      for (const result of messageIDConflictCheckResults) {
+        if (!result.isProcessingPossible) {
+          return result;
+        }
       }
-      return {
-        isProcessingPossible: false,
-        reason: {
-          type: 'missing_thread',
-          threadID: dmOperation.threadID,
-        },
-      };
+
+      if (!utilities.threadInfos[dmOperation.threadID]) {
+        return {
+          isProcessingPossible: false,
+          reason: {
+            type: 'missing_thread',
+            threadID: dmOperation.threadID,
+          },
+        };
+      }
+      return { isProcessingPossible: true };
     },
     supportsAutoRetry: true,
   });
diff --git a/lib/shared/dm-ops/create-entry-spec.js b/lib/shared/dm-ops/create-entry-spec.js
--- a/lib/shared/dm-ops/create-entry-spec.js
+++ b/lib/shared/dm-ops/create-entry-spec.js
@@ -79,6 +79,18 @@
     dmOperation: DMCreateEntryOperation,
     utilities: ProcessDMOperationUtilities,
   ) => {
+    if (utilities.entryInfos[dmOperation.entryID]) {
+      console.log(
+        'Discarded a CREATE_ENTRY operation because entry with ' +
+          `the same ID ${dmOperation.entryID} already exists in the store`,
+      );
+      return {
+        isProcessingPossible: false,
+        reason: {
+          type: 'invalid',
+        },
+      };
+    }
     if (utilities.threadInfos[dmOperation.threadID]) {
       return { isProcessingPossible: true };
     }
diff --git a/lib/shared/dm-ops/create-sidebar-spec.js b/lib/shared/dm-ops/create-sidebar-spec.js
--- a/lib/shared/dm-ops/create-sidebar-spec.js
+++ b/lib/shared/dm-ops/create-sidebar-spec.js
@@ -188,6 +188,19 @@
       dmOperation: DMCreateSidebarOperation,
       utilities: ProcessDMOperationUtilities,
     ) => {
+      if (utilities.threadInfos[dmOperation.threadID]) {
+        console.log(
+          'Discarded a CREATE_SIDEBAR operation because thread ' +
+            `with the same ID ${dmOperation.threadID} already exists ` +
+            'in the store',
+        );
+        return {
+          isProcessingPossible: false,
+          reason: {
+            type: 'invalid',
+          },
+        };
+      }
       const sourceMessage = await utilities.fetchMessage(
         dmOperation.sourceMessageID,
       );
diff --git a/lib/shared/dm-ops/create-thread-spec.js b/lib/shared/dm-ops/create-thread-spec.js
--- a/lib/shared/dm-ops/create-thread-spec.js
+++ b/lib/shared/dm-ops/create-thread-spec.js
@@ -289,7 +289,23 @@
         blobOps: [],
       };
     },
-    canBeProcessed: async () => {
+    canBeProcessed: async (
+      dmOperation: DMCreateThreadOperation,
+      utilities: ProcessDMOperationUtilities,
+    ) => {
+      if (utilities.threadInfos[dmOperation.threadID]) {
+        console.log(
+          'Discarded a CREATE_THREAD operation because thread ' +
+            `with the same ID ${dmOperation.threadID} already exists ` +
+            'in the store',
+        );
+        return {
+          isProcessingPossible: false,
+          reason: {
+            type: 'invalid',
+          },
+        };
+      }
       return { isProcessingPossible: true };
     },
     supportsAutoRetry: true,
diff --git a/lib/shared/dm-ops/dm-op-spec.js b/lib/shared/dm-ops/dm-op-spec.js
--- a/lib/shared/dm-ops/dm-op-spec.js
+++ b/lib/shared/dm-ops/dm-op-spec.js
@@ -18,7 +18,7 @@
   ) => Promise<UserIdentitiesResponse>,
 };
 
-type ProcessingPossibilityCheckResult =
+export type ProcessingPossibilityCheckResult =
   | { +isProcessingPossible: true }
   | {
       +isProcessingPossible: false,
diff --git a/lib/shared/dm-ops/dm-op-utils.js b/lib/shared/dm-ops/dm-op-utils.js
--- a/lib/shared/dm-ops/dm-op-utils.js
+++ b/lib/shared/dm-ops/dm-op-utils.js
@@ -5,7 +5,10 @@
 import * as React from 'react';
 import uuid from 'uuid';
 
-import { type ProcessDMOperationUtilities } from './dm-op-spec.js';
+import {
+  type ProcessDMOperationUtilities,
+  type ProcessingPossibilityCheckResult,
+} from './dm-op-spec.js';
 import { dmOpSpecs } from './dm-op-specs.js';
 import { useProcessAndSendDMOperation } from './process-dm-ops.js';
 import { mergeUpdatesWithMessageInfos } from '../../reducers/message-reducer.js';
@@ -359,9 +362,39 @@
   return newUpdateInfos;
 }
 
+async function checkMessageIDConflict(
+  dmOperation: DMOperation,
+  utilities: ProcessDMOperationUtilities,
+): Promise<ProcessingPossibilityCheckResult> {
+  if (!dmOperation.messageID) {
+    return {
+      isProcessingPossible: true,
+    };
+  }
+  const messageID = dmOperation.messageID;
+  const message = await utilities.fetchMessage(messageID);
+  if (message) {
+    console.log(
+      `Discarded a ${dmOperation.type} operation because ` +
+        `message with the same ID ${messageID} already exists ` +
+        'in the store',
+    );
+    return {
+      isProcessingPossible: false,
+      reason: {
+        type: 'invalid',
+      },
+    };
+  }
+  return {
+    isProcessingPossible: true,
+  };
+}
+
 export {
   createMessagesToPeersFromDMOp,
   useAddDMThreadMembers,
   getCreateThickRawThreadInfoInputFromThreadInfo,
   getThreadUpdatesForNewMessages,
+  checkMessageIDConflict,
 };
diff --git a/lib/shared/dm-ops/process-dm-ops.js b/lib/shared/dm-ops/process-dm-ops.js
--- a/lib/shared/dm-ops/process-dm-ops.js
+++ b/lib/shared/dm-ops/process-dm-ops.js
@@ -12,6 +12,7 @@
   dmOperationSpecificationTypes,
   type OutboundComposableDMOperationSpecification,
   getThreadUpdatesForNewMessages,
+  checkMessageIDConflict,
 } from './dm-op-utils.js';
 import { useProcessBlobHolders } from '../../actions/holder-actions.js';
 import {
@@ -146,6 +147,14 @@
         return;
       }
 
+      const messageIDConflictCheckResult = await checkMessageIDConflict(
+        dmOp,
+        utilities,
+      );
+      if (!messageIDConflictCheckResult.isProcessingPossible) {
+        return;
+      }
+
       const processingCheckResult = await dmOpSpecs[dmOp.type].canBeProcessed(
         dmOp,
         utilities,
diff --git a/lib/shared/dm-ops/send-edit-message-spec.js b/lib/shared/dm-ops/send-edit-message-spec.js
--- a/lib/shared/dm-ops/send-edit-message-spec.js
+++ b/lib/shared/dm-ops/send-edit-message-spec.js
@@ -51,8 +51,10 @@
       dmOperation: DMSendEditMessageOperation,
       utilities: ProcessDMOperationUtilities,
     ) => {
-      const message = await utilities.fetchMessage(dmOperation.targetMessageID);
-      if (!message) {
+      const targetMessage = await utilities.fetchMessage(
+        dmOperation.targetMessageID,
+      );
+      if (!targetMessage) {
         return {
           isProcessingPossible: false,
           reason: {
diff --git a/lib/shared/dm-ops/send-multimedia-message-spec.js b/lib/shared/dm-ops/send-multimedia-message-spec.js
--- a/lib/shared/dm-ops/send-multimedia-message-spec.js
+++ b/lib/shared/dm-ops/send-multimedia-message-spec.js
@@ -89,16 +89,16 @@
       dmOperation: DMSendMultimediaMessageOperation,
       utilities: ProcessDMOperationUtilities,
     ) => {
-      if (utilities.threadInfos[dmOperation.threadID]) {
-        return { isProcessingPossible: true };
+      if (!utilities.threadInfos[dmOperation.threadID]) {
+        return {
+          isProcessingPossible: false,
+          reason: {
+            type: 'missing_thread',
+            threadID: dmOperation.threadID,
+          },
+        };
       }
-      return {
-        isProcessingPossible: false,
-        reason: {
-          type: 'missing_thread',
-          threadID: dmOperation.threadID,
-        },
-      };
+      return { isProcessingPossible: true };
     },
     supportsAutoRetry: false,
   });
diff --git a/lib/shared/dm-ops/send-reaction-message-spec.js b/lib/shared/dm-ops/send-reaction-message-spec.js
--- a/lib/shared/dm-ops/send-reaction-message-spec.js
+++ b/lib/shared/dm-ops/send-reaction-message-spec.js
@@ -59,8 +59,10 @@
       dmOperation: DMSendReactionMessageOperation,
       utilities: ProcessDMOperationUtilities,
     ) => {
-      const message = await utilities.fetchMessage(dmOperation.targetMessageID);
-      if (!message) {
+      const targetMessage = await utilities.fetchMessage(
+        dmOperation.targetMessageID,
+      );
+      if (!targetMessage) {
         return {
           isProcessingPossible: false,
           reason: {
diff --git a/lib/shared/dm-ops/send-text-message-spec.js b/lib/shared/dm-ops/send-text-message-spec.js
--- a/lib/shared/dm-ops/send-text-message-spec.js
+++ b/lib/shared/dm-ops/send-text-message-spec.js
@@ -50,16 +50,16 @@
       dmOperation: DMSendTextMessageOperation,
       utilities: ProcessDMOperationUtilities,
     ) => {
-      if (utilities.threadInfos[dmOperation.threadID]) {
-        return { isProcessingPossible: true };
+      if (!utilities.threadInfos[dmOperation.threadID]) {
+        return {
+          isProcessingPossible: false,
+          reason: {
+            type: 'missing_thread',
+            threadID: dmOperation.threadID,
+          },
+        };
       }
-      return {
-        isProcessingPossible: false,
-        reason: {
-          type: 'missing_thread',
-          threadID: dmOperation.threadID,
-        },
-      };
+      return { isProcessingPossible: true };
     },
     supportsAutoRetry: false,
   });