diff --git a/native/package.json b/native/package.json
--- a/native/package.json
+++ b/native/package.json
@@ -19,7 +19,7 @@
     "logfirebase": "adb shell logcat | grep -E -i 'FIRMessagingModule|firebase'",
     "redux-devtools": "redux-devtools --port=8043 --open",
     "codegen-jsi": "flow && babel codegen/src/ -d codegen/dist/ && node codegen/dist",
-    "react-native": "PATH=/usr/bin:/bin:\"$PATH\" react-native",
+    "react-native": "./scripts/run-react-native.sh",
     "expo": "PATH=/usr/bin:/bin:\"$PATH\" expo",
     "xcodebuild": "cd ios && PATH=/usr/bin:/bin:\"$PATH\" xcodebuild",
     "update-version": "node scripts/update-mobile-version.mjs",
diff --git a/native/scripts/run-react-native.sh b/native/scripts/run-react-native.sh
new file mode 100755
--- /dev/null
+++ b/native/scripts/run-react-native.sh
@@ -0,0 +1,32 @@
+#!/usr/bin/env bash
+
+# This script is necessary for running react-native CLI commands from the Nix environment
+# We need it because the Nix environment overrides a bunch of compiler env vars
+# Our Rust build has dependencies that assume the standard macOS compiler environment
+
+set -euo pipefail
+
+export CPATH=
+export CPLUS_INCLUDE_PATH=
+export OBJC_INCLUDE_PATH=
+
+CC=$(/usr/bin/xcrun --sdk macosx --find clang)
+CXX=$(/usr/bin/xcrun --sdk macosx --find clang++)
+export CC
+export CXX
+
+SDKROOT=$(/usr/bin/xcrun --sdk macosx --show-sdk-path)
+export SDKROOT
+export CFLAGS="-isysroot $SDKROOT"
+export RUSTFLAGS="-C link-arg=-isysroot -C link-arg=$SDKROOT -C link-arg=-Wl,-search_paths_first"
+
+DEVELOPER_DIR=$(/usr/bin/xcode-select -p)
+DEVELOPER_BIN="$DEVELOPER_DIR/usr/bin"
+TOOLCHAIN_DIR="$DEVELOPER_DIR/Toolchains/XcodeDefault.xctoolchain"
+TOOLCHAIN_BIN="$TOOLCHAIN_DIR/usr/bin"
+TOOLCHAIN_INCLUDE="$TOOLCHAIN_DIR/usr/include/c++/v1"
+
+export PATH="$TOOLCHAIN_BIN:$DEVELOPER_BIN:/usr/bin:/bin:$PATH"
+export CXXFLAGS="-isysroot $SDKROOT -stdlib=libc++ -isystem $TOOLCHAIN_INCLUDE"
+
+exec react-native "$@"