diff --git a/lib/hooks/input-state-container-hooks.js b/lib/hooks/input-state-container-hooks.js
--- a/lib/hooks/input-state-container-hooks.js
+++ b/lib/hooks/input-state-container-hooks.js
@@ -18,6 +18,7 @@
 import { messageTypes } from '../types/message-types-enum.js';
 import type {
   RawMultimediaMessageInfo,
+  ReplyParameters,
   SendMessagePayload,
   SendMultimediaMessagePayload,
 } from '../types/message-types.js';
@@ -31,6 +32,7 @@
   parentThreadInfo: ?ThreadInfo,
   sidebarCreation: boolean,
   threadCreation: boolean,
+  reply?: ?ReplyParameters,
 ) => Promise<SendMessagePayload> {
   const sendKeyserverTextMessage = useSendTextMessage();
   const sendComposableDMOperation = useSendComposableDMOperation();
@@ -49,6 +51,7 @@
       parentThreadInfo: ?ThreadInfo,
       sidebarCreation: boolean,
       threadCreation: boolean,
+      reply?: ?ReplyParameters,
     ) => {
       invariant(viewerID, 'Viewer ID should be present');
       return threadSpecs[threadInfo.type].protocol().sendTextMessage(
@@ -58,6 +61,7 @@
           parentThreadInfo,
           sidebarCreation,
           threadCreation,
+          reply,
         },
         {
           sendKeyserverTextMessage,
diff --git a/lib/shared/farcaster/farcaster-api.js b/lib/shared/farcaster/farcaster-api.js
--- a/lib/shared/farcaster/farcaster-api.js
+++ b/lib/shared/farcaster/farcaster-api.js
@@ -37,8 +37,9 @@
   | {
       +groupId: string,
       +message: string,
+      +inReplyToMessageId?: string,
     }
-  | { +recipientFid: number, +message: string };
+  | { +recipientFid: number, +message: string, +inReplyToMessageId?: string };
 
 type SendFarcasterMessageResultData = {
   +messageId: string,
diff --git a/lib/shared/threads/protocols/farcaster-thread-protocol.js b/lib/shared/threads/protocols/farcaster-thread-protocol.js
--- a/lib/shared/threads/protocols/farcaster-thread-protocol.js
+++ b/lib/shared/threads/protocols/farcaster-thread-protocol.js
@@ -23,6 +23,7 @@
 import {
   defaultNumberPerThread,
   messageTruncationStatus,
+  type ReplyParameters,
   type SendMessagePayload,
   type SendMultimediaMessagePayload,
 } from '../../../types/message-types.js';
@@ -126,6 +127,7 @@
   rawThreadInfos,
   farcasterFetchConversation,
   threadCreation,
+  reply,
 }: {
   threadInfo: ThreadInfo | RawThreadInfo,
   viewerID: string,
@@ -137,9 +139,17 @@
     conversationID: string,
   ) => Promise<?FarcasterConversation>,
   threadCreation: boolean,
+  reply?: ?ReplyParameters,
 }) {
   const time = Date.now();
 
+  let messageText = text;
+  let targetMessageID = null;
+  if (reply && text.startsWith(reply.messagePrefix)) {
+    messageText = text.slice(reply.messagePrefix.length);
+    targetMessageID = reply.targetMessageID;
+  }
+
   let request;
   if (threadInfo.type === farcasterThreadTypes.FARCASTER_PERSONAL) {
     const otherUser = getSingleOtherUser(threadInfo, viewerID);
@@ -158,13 +168,15 @@
     const recipientFID = parseInt(targetFID, 10);
     request = {
       recipientFid: recipientFID,
-      message: text,
+      message: messageText,
+      ...(targetMessageID ? { inReplyToMessageId: targetMessageID } : {}),
     };
   } else {
     const conversationID = conversationIDFromFarcasterThreadID(threadInfo.id);
     request = {
       groupId: conversationID,
-      message: text,
+      message: messageText,
+      ...(targetMessageID ? { inReplyToMessageId: targetMessageID } : {}),
     };
   }
 
@@ -193,7 +205,7 @@
       farcasterFetchConversation,
       rawThreadInfos,
     } = utils;
-    const { messageInfo, threadInfo, threadCreation } = message;
+    const { messageInfo, threadInfo, threadCreation, reply } = message;
     const { localID } = messageInfo;
     invariant(
       localID !== null && localID !== undefined,
@@ -209,6 +221,7 @@
       rawThreadInfos,
       farcasterFetchConversation,
       threadCreation,
+      reply,
     });
 
     return {
diff --git a/lib/shared/threads/thread-spec.js b/lib/shared/threads/thread-spec.js
--- a/lib/shared/threads/thread-spec.js
+++ b/lib/shared/threads/thread-spec.js
@@ -57,6 +57,7 @@
   FetchPinnedMessagesResult,
   RawMessageInfo,
   MessageInfo,
+  ReplyParameters,
 } from '../../types/message-types.js';
 import type { RawTextMessageInfo } from '../../types/messages/text.js';
 import type {
@@ -132,6 +133,7 @@
   +parentThreadInfo: ?ThreadInfo,
   +sidebarCreation: boolean,
   +threadCreation: boolean,
+  +reply?: ?ReplyParameters,
 };
 export type SendTextMessageUtils = {
   +sendKeyserverTextMessage: SendTextMessageInput => Promise<SendMessageResult>,
diff --git a/lib/types/message-types.js b/lib/types/message-types.js
--- a/lib/types/message-types.js
+++ b/lib/types/message-types.js
@@ -224,6 +224,11 @@
 // Raw*MessageInfo = used by server, and contained in client's local store
 // *MessageInfo = used by client in UI code
 
+export type ReplyParameters = {
+  +targetMessageID: string,
+  +messagePrefix: string,
+};
+
 export type ValidRawSidebarSourceMessageInfo =
   | RawTextMessageInfo
   | RawCreateThreadMessageInfo
diff --git a/native/chat/composed-message.react.js b/native/chat/composed-message.react.js
--- a/native/chat/composed-message.react.js
+++ b/native/chat/composed-message.react.js
@@ -13,6 +13,7 @@
 
 import { chatMessageItemHasEngagement } from 'lib/shared/chat-message-item-utils.js';
 import { getMessageLabel } from 'lib/shared/edit-messages-utils.js';
+import { messageID } from 'lib/shared/id-utils.js';
 import { createMessageReply } from 'lib/shared/markdown.js';
 import { assertComposableMessageType } from 'lib/types/message-types.js';
 
@@ -159,15 +160,15 @@
       sendFailed,
     ]);
 
-    const editInputMessage = inputState?.editInputMessage;
     const reply = React.useCallback(() => {
-      invariant(editInputMessage, 'editInputMessage should be set in reply');
+      invariant(inputState, 'Input state should be set in reply');
       invariant(item.messageInfo.text, 'text should be set in reply');
-      editInputMessage({
-        message: createMessageReply(item.messageInfo.text),
-        mode: 'prepend',
+      const messagePrefix = createMessageReply(item.messageInfo.text);
+      inputState.replyToMessage({
+        targetMessageID: messageID(item.messageInfo),
+        messagePrefix,
       });
-    }, [editInputMessage, item.messageInfo.text]);
+    }, [inputState, item.messageInfo]);
 
     const triggerReply =
       swipeOptions === 'reply' || swipeOptions === 'both' ? reply : undefined;
diff --git a/native/chat/text-message-tooltip-modal.react.js b/native/chat/text-message-tooltip-modal.react.js
--- a/native/chat/text-message-tooltip-modal.react.js
+++ b/native/chat/text-message-tooltip-modal.react.js
@@ -4,6 +4,7 @@
 import invariant from 'invariant';
 import * as React from 'react';
 
+import { messageID } from 'lib/shared/id-utils.js';
 import { createMessageReply } from 'lib/shared/markdown.js';
 import { useDeleteMessage } from 'lib/utils/delete-message-utils.js';
 
@@ -51,11 +52,17 @@
       'inputState should be set in TextMessageTooltipModal.onPressReply',
     );
     navigateToThread({ threadInfo });
-    inputState.editInputMessage({
-      message: createMessageReply(text),
-      mode: 'prepend',
+    inputState.replyToMessage({
+      targetMessageID: messageID(route.params.item.messageInfo),
+      messagePrefix: createMessageReply(text),
     });
-  }, [inputState, navigateToThread, threadInfo, text]);
+  }, [
+    inputState,
+    navigateToThread,
+    route.params.item.messageInfo,
+    text,
+    threadInfo,
+  ]);
   const renderReplyIcon = React.useCallback(
     (style: TextStyle) => <CommIcon name="reply" style={style} size={12} />,
     [],
diff --git a/native/input/input-state-container.react.js b/native/input/input-state-container.react.js
--- a/native/input/input-state-container.react.js
+++ b/native/input/input-state-container.react.js
@@ -73,6 +73,7 @@
 import {
   type RawMessageInfo,
   type RawMultimediaMessageInfo,
+  type ReplyParameters,
   type SendMessagePayload,
   type SendMultimediaMessagePayload,
 } from 'lib/types/message-types.js';
@@ -165,6 +166,7 @@
     parentThreadInfo: ?ThreadInfo,
     sidebarCreation: boolean,
     threadCreation: boolean,
+    reply?: ?ReplyParameters,
   ) => Promise<SendMessagePayload>,
   +newThinThread: (
     request: ClientNewThinThreadRequest,
@@ -181,11 +183,13 @@
 };
 type State = {
   +pendingUploads: PendingMultimediaUploads,
+  +reply: ?ReplyParameters,
 };
 
 class InputStateContainer extends React.PureComponent<Props, State> {
   state: State = {
     pendingUploads: {},
+    reply: null,
   };
   sendCallbacks: Array<() => void> = [];
   activeURIs: Map<string, ActiveURI> = new Map();
@@ -436,6 +440,7 @@
         sendTextMessage: this.sendTextMessage,
         sendMultimediaMessage: this.sendMultimediaMessage,
         editInputMessage: this.editInputMessage,
+        replyToMessage: this.replyToMessage,
         addEditInputMessageListener: this.addEditInputMessageListener,
         removeEditInputMessageListener: this.removeEditInputMessageListener,
         messageHasUploadFailure: this.messageHasUploadFailure,
@@ -622,6 +627,8 @@
     const sidebarCreation =
       this.pendingSidebarCreationMessageLocalIDs.has(localID);
 
+    const reply = this.state.reply;
+
     try {
       const result = await this.props.sendTextMessage(
         messageInfo,
@@ -629,8 +636,10 @@
         parentThreadInfo,
         sidebarCreation,
         threadCreation,
+        reply,
       );
       this.pendingSidebarCreationMessageLocalIDs.delete(localID);
+      this.setState({ reply: null });
       return result;
     } catch (e) {
       if (e instanceof SendMessageError) {
@@ -1371,6 +1380,16 @@
     );
   };
 
+  replyToMessage = (params: ReplyParameters) => {
+    this.editInputMessage({
+      message: params.messagePrefix,
+      mode: 'prepend',
+    });
+    this.setState({
+      reply: params,
+    });
+  };
+
   addEditInputMessageListener = (
     callbackEditInputBar: (params: EditInputBarMessageParameters) => void,
   ) => {
diff --git a/native/input/input-state.js b/native/input/input-state.js
--- a/native/input/input-state.js
+++ b/native/input/input-state.js
@@ -3,6 +3,7 @@
 import * as React from 'react';
 
 import type { NativeMediaSelection } from 'lib/types/media-types.js';
+import type { ReplyParameters } from 'lib/types/message-types.js';
 import type { RawTextMessageInfo } from 'lib/types/messages/text.js';
 import type { ThreadInfo } from 'lib/types/minimally-encoded-thread-permissions-types.js';
 
@@ -39,6 +40,7 @@
     threadInfo: ThreadInfo,
   ) => Promise<void>,
   +editInputMessage: (params: EditInputBarMessageParameters) => void,
+  +replyToMessage: (params: ReplyParameters) => void,
   +addEditInputMessageListener: (
     (params: EditInputBarMessageParameters) => void,
   ) => void,
diff --git a/web/chat/chat-input-bar.react.js b/web/chat/chat-input-bar.react.js
--- a/web/chat/chat-input-bar.react.js
+++ b/web/chat/chat-input-bar.react.js
@@ -38,6 +38,7 @@
 import type { CalendarQuery } from 'lib/types/entry-types.js';
 import type { LoadingStatus } from 'lib/types/loading-types.js';
 import { messageTypes } from 'lib/types/message-types-enum.js';
+import type { ReplyParameters } from 'lib/types/message-types.js';
 import type {
   ThreadInfo,
   RawThreadInfo,
@@ -427,7 +428,8 @@
     );
   };
 
-  focusAndUpdateText = (text: string) => {
+  focusAndUpdateText = (params: ReplyParameters) => {
+    const text = params.messagePrefix;
     // We need to call focus() first on Safari, otherwise the cursor
     // ends up at the start instead of the end for some reason
     const { textarea } = this;
diff --git a/web/input/input-state-container.react.js b/web/input/input-state-container.react.js
--- a/web/input/input-state-container.react.js
+++ b/web/input/input-state-container.react.js
@@ -74,6 +74,7 @@
   type RawMultimediaMessageInfo,
   type SendMessagePayload,
   type SendMultimediaMessagePayload,
+  type ReplyParameters,
 } from 'lib/types/message-types.js';
 import type { RawImagesMessageInfo } from 'lib/types/messages/images.js';
 import type { RawMediaMessageInfo } from 'lib/types/messages/media.js';
@@ -155,6 +156,7 @@
     parentThreadInfo: ?ThreadInfo,
     sidebarCreation: boolean,
     threadCreation: boolean,
+    reply?: ?ReplyParameters,
   ) => Promise<SendMessagePayload>,
   +newThinThread: (
     request: ClientNewThinThreadRequest,
@@ -180,6 +182,7 @@
   },
   textCursorPositions: { [threadID: string]: number },
   typeaheadState: TypeaheadState,
+  reply: ?ReplyParameters,
 };
 type State = $ReadOnly<WritableState>;
 
@@ -202,8 +205,9 @@
       close: null,
       accept: null,
     },
+    reply: null,
   };
-  replyCallbacks: Array<(message: string) => void> = [];
+  replyCallbacks: Array<(params: ReplyParameters) => void> = [];
   pendingThreadCreations: Map<
     string,
     Promise<{
@@ -690,7 +694,7 @@
                 threadInfo,
                 assignedUploads[localMessageID],
               ),
-            addReply: (message: string) => this.addReply(message),
+            addReply: (params: ReplyParameters) => this.addReply(params),
             addReplyListener: this.addReplyListener,
             removeReplyListener: this.removeReplyListener,
             registerSendCallback: this.props.registerSendCallback,
@@ -1420,6 +1424,8 @@
     const sidebarCreation =
       this.pendingSidebarCreationMessageLocalIDs.has(localID);
 
+    const reply = this.state.reply;
+
     try {
       const result = await this.props.sendTextMessage(
         messageInfo,
@@ -1427,8 +1433,10 @@
         parentThreadInfo,
         sidebarCreation,
         threadCreation,
+        reply,
       );
       this.pendingSidebarCreationMessageLocalIDs.delete(localID);
+      this.setState({ reply: null });
       return result;
     } catch (e) {
       if (e instanceof SendMessageError) {
@@ -1659,15 +1667,16 @@
     void this.uploadFiles(threadInfo, uploadsToRetry);
   }
 
-  addReply = (message: string) => {
-    this.replyCallbacks.forEach(addReplyCallback => addReplyCallback(message));
+  addReply = (params: ReplyParameters) => {
+    this.replyCallbacks.forEach(addReplyCallback => addReplyCallback(params));
+    this.setState({ reply: params });
   };
 
-  addReplyListener = (callbackReply: (message: string) => void) => {
+  addReplyListener = (callbackReply: (params: ReplyParameters) => void) => {
     this.replyCallbacks.push(callbackReply);
   };
 
-  removeReplyListener = (callbackReply: (message: string) => void) => {
+  removeReplyListener = (callbackReply: (params: ReplyParameters) => void) => {
     this.replyCallbacks = this.replyCallbacks.filter(
       candidate => candidate !== callbackReply,
     );
diff --git a/web/input/input-state.js b/web/input/input-state.js
--- a/web/input/input-state.js
+++ b/web/input/input-state.js
@@ -8,6 +8,7 @@
   type MediaMissionStep,
   type MediaType,
 } from 'lib/types/media-types.js';
+import type { ReplyParameters } from 'lib/types/message-types.js';
 import type { RawTextMessageInfo } from 'lib/types/messages/text.js';
 import type {
   RelativeMemberInfo,
@@ -80,9 +81,9 @@
     localMessageID: string,
     threadInfo: ThreadInfo,
   ) => void,
-  +addReply: (text: string) => void,
-  +addReplyListener: ((message: string) => void) => void,
-  +removeReplyListener: ((message: string) => void) => void,
+  +addReply: (params: ReplyParameters) => void,
+  +addReplyListener: ((params: ReplyParameters) => void) => void,
+  +removeReplyListener: ((params: ReplyParameters) => void) => void,
   +registerSendCallback: (() => mixed) => void,
   +unregisterSendCallback: (() => mixed) => void,
 };
diff --git a/web/tooltips/tooltip-action-utils.js b/web/tooltips/tooltip-action-utils.js
--- a/web/tooltips/tooltip-action-utils.js
+++ b/web/tooltips/tooltip-action-utils.js
@@ -17,6 +17,7 @@
   chatMessageItemEngagementTargetMessageInfo,
 } from 'lib/shared/chat-message-item-utils.js';
 import { useCanEditMessage } from 'lib/shared/edit-messages-utils.js';
+import { messageID } from 'lib/shared/id-utils.js';
 import { createMessageReply } from 'lib/shared/markdown.js';
 import { useCanCreateReactionFromMessage } from 'lib/shared/reaction-utils.js';
 import { useSidebarExistsOrCanBeCreated } from 'lib/shared/sidebar-utils.js';
@@ -209,7 +210,10 @@
       if (!messageInfo.text) {
         return;
       }
-      addReply(createMessageReply(messageInfo.text));
+      addReply({
+        targetMessageID: messageID(messageInfo),
+        messagePrefix: createMessageReply(messageInfo.text),
+      });
     };
     return {
       actionButtonContent: buttonContent,