diff --git a/web/database/sqlite-data-handler.js b/web/database/sqlite-data-handler.js
--- a/web/database/sqlite-data-handler.js
+++ b/web/database/sqlite-data-handler.js
@@ -1,5 +1,6 @@
 // @flow
 
+import localforage from 'localforage';
 import * as React from 'react';
 import { useDispatch } from 'react-redux';
 
@@ -7,9 +8,30 @@
 import { convertClientDBReportToClientReportCreationRequest } from 'lib/ops/report-store-ops.js';
 
 import { databaseModule } from './database-module-provider.js';
+import { SQLITE_ENCRYPTION_KEY } from './utils/constants.js';
+import { isDesktopSafari } from './utils/db-utils.js';
+import {
+  exportKeyToJWK,
+  generateDatabaseCryptoKey,
+} from './utils/worker-crypto-utils.js';
 import { useSelector } from '../redux/redux-utils.js';
 import { workerRequestMessageTypes } from '../types/worker-types.js';
 
+async function getSafariEncryptionKey(): Promise<?SubtleCrypto$JsonWebKey> {
+  if (!isDesktopSafari()) {
+    return null;
+  }
+  const encryptionKey = await localforage.getItem(SQLITE_ENCRYPTION_KEY);
+  if (encryptionKey) {
+    return await exportKeyToJWK(encryptionKey);
+  }
+  const newEncryptionKey = await generateDatabaseCryptoKey({
+    extractable: true,
+  });
+  await localforage.setItem(SQLITE_ENCRYPTION_KEY, newEncryptionKey);
+  return await exportKeyToJWK(newEncryptionKey);
+}
+
 function SQLiteDataHandler(): React.Node {
   const dispatch = useDispatch();
   const rehydrateConcluded = useSelector(
@@ -47,7 +69,11 @@
   React.useEffect(() => {
     (async () => {
       if (currentLoggedInUserID) {
-        await databaseModule.initDBForLoggedInUser(currentLoggedInUserID);
+        const databaseEncryptionKeyJWK = await getSafariEncryptionKey();
+        await databaseModule.initDBForLoggedInUser(
+          currentLoggedInUserID,
+          databaseEncryptionKeyJWK,
+        );
       }
 
       if (!rehydrateConcluded) {
diff --git a/web/database/utils/db-utils.js b/web/database/utils/db-utils.js
--- a/web/database/utils/db-utils.js
+++ b/web/database/utils/db-utils.js
@@ -45,4 +45,9 @@
   );
 }
 
-export { parseMultiStatementSQLiteResult, isSQLiteSupported };
+function isDesktopSafari(): boolean {
+  const browser = detectBrowser();
+  return browser.name === 'safari' && browser.os === 'Mac OS';
+}
+
+export { parseMultiStatementSQLiteResult, isSQLiteSupported, isDesktopSafari };